genetic mutation

noun

plural genetic mutations

: a permanent alteration in the nucleotide sequence of one or more genes or in the number or structure of one or more chromosomes

Lacking working copies of the p53 gene, cells can begin to divide without check, though several other genetic mutations are thought to be needed to foster a full-blown malignancy.

—Natalie Angier

Examples of genetic mutation in a Sentence

Recent Examples on the Web

Scientists say the split coloring is likely caused by a genetic mutation or pigment irregularities, and aquarium biologist Julia Studley broke down the specific mechanism for Popular Science. —Hanna Wickes, Miami Herald, 27 Apr. 2026

The Science Behind the Split Shell Scientists say the split coloring is likely caused by a genetic mutation or pigment irregularities. —Hanna Wickes, Kansas City Star, 27 Apr. 2026

Jin says as many as a fifth of patients have hereditary markers — like a genetic mutation for Lynch syndrome — that increase the risk of getting colorectal cancer, among others. —Yuki Noguchi, NPR, 27 Apr. 2026

How Two Eggs Became One Lobster Scientists say the split coloring is likely caused by a genetic mutation or pigment irregularities. —Hanna Wickes, Charlotte Observer, 27 Apr. 2026

Word History

First Known Use

1915, in the meaning defined above

Rhymes for genetic mutation

• acclimatisation
• acclimatization
• acidification
• actualization
• annualization
• autocorrelation
• autoregulation
• beatification
• beneficiation
• biodegradation
• biotransformation
• bureaucratization

Medical Definition

genetic mutation

noun

: a permanent alteration in the nucleotide sequence of one or more genes or in the number or structure of one or more chromosomes

Gaucher's disease results from one of many genetic mutations that can either slow or prevent the breakdown of certain glycolipids, which accumulate in storage vesicles and eventually kill cells.

—Joseph Alper